SCIENZE BIOLOGICHE, GEOLOGICHE E AMBIENTALIExperimental and Applied BiologyAcademic Year 2022/2023

72893 - FARMACOLOGIA

Teacher: Mariangela CHISARI

Expected Learning Outcomes

Students will focus and understand phenomena that influence pharmacokinetics and pharmacodynamics, the mechanisms of action and the signal transduction pathways of dugs, and adverse reactions to medications. Moreover, selected classes of drugs that are particularly relevant in midwifery will be discussed

Course Structure

Traditional classes. Students are invited to actively participate with questions and comments on discussed topics.

If the teaching is given in a mixed or remote mode, necessary changes may be introduced in order to fullfill all statements in the Syllabus.

Required Prerequisites

Basic knowledge in the following topics: Anatomy, Histology, Biochemistry, Physiology, Pathology, Microbiology

Attendance of Lessons

Mandatory attendance to classes, except for new instructions for contingent reasons

Detailed Course Content

General Pharmacology

General principles of pharmacology;
Development of a drug;
Routes of administration;
Pharmacokinetics: absorption, diffusion, metabolism and elimination of drugs;
Pharmacodynamics: biological targets of drugs, classification of receptors and receptor theories, concentration-response curve;
Signal transduction mechanisms;
Agonists and antagonists;
Factors that influence the response to drugs;
Adverse drug reactions

Clinical Pharmacology

Neurotransmitters and neuromodulators (synthesis, metabolism, distribution, functions, targets, drugs): acetylcholine, adrenaline and noradrenaline, dopamine, serotonin, GABA, glutamate, histamine, opioids, arachidonic acid
General and local anesthetics;
Drugs of the cardiovascular system, blood and kidney;
Diabetes medications;
Notes on drugs active on the gastrointestinal system;
General principles of antibacterial and antitumor chemotherapy.

Textbook Information

Rossi - Cuomo - Riccardi: Farmacologia - Principi di base e applicazioni terapeutiche, Minerva Medica, Edizione III e successive
Rang - Dale: Farmacologia, Ed. Edra, Edizione VIII e successive
Katzung - Preziosi - Masters – Trevor: Farmacologia Generale e Clinica, Piccin, Edizione IX e successive

Course Planning

	Subjects	Text References
1	General principles	see texbook tab
2	Drug development	see texbook tab
3	Drug administration routes	see texbook tab
4	Pharmacokinetics: absorption, diffusion, metabolism and elimination of drugs	see texbook tab
5	Pharmacodynamics: biological targets of drugs, classification of receptors and receptor theories, concentration-response curve	see texbook tab
6	Signal transduction mechanisms	see texbook tab
7	Agonists and antagonists	see texbook tab
8	Varaibility of therapeutic intervention	see texbook tab
9	Adverse drug reactions	see texbook tab
10	Neurotransmitters and neuromodulators (synthesis, metabolism, distribution, functions, targets, drugs): acetylcholine, adrenaline and noradrenaline, dopamine, serotonin, GABA, glutamate, histamine, opioids, arachidonic acid	see texbook tab
11	General and local anesthetics	see texbook tab
12	Drugs of the cardiovascular system, and active on the blood and the kidney	see texbook tab
13	Diabetes mellitus medications	see texbook tab
14	Brief summary of drugs active on the GI system	see texbook tab
15	General principles of antibacterial and antitumor chemotherapy	see texbook tab

Learning Assessment

Learning Assessment Procedures

Written test and oral exam about topics listed in the program and discussed during classes. The final evaluation will be determined by appropriate use of the scientific language, the ability to explain what has been learned, as well as by the skills of critical thinking.

Examples of frequently asked questions and / or exercises

Concentration-response curve; teratogenesis; diabetes mellitus medications; antibiotics

Versione in italiano