1007334 - SCIENZE DI MEDICINA DI LABORATORIO
Module 1007335 - BIOCHIMICA CLINICA E BIOLOGIA MOLECOLARE CLINICA
Expected Learning Outcomes
The phases that determine the results of the biochemical-clinical-molecular analyzes. The clinical question, the pre-analytical, analytical and post-analytical phases. Biological samples. The main laboratory methods applicable to the qualitative and quantitative study of analytes and biological processes; acquisition of the ability to correctly apply the methodologies aimed at obtaining useful data for the correct interpretation for the purposes of diagnosis and prognosis; ability to evaluate cost / benefit ratios in the choice of diagnostic procedures, taking into account the needs of both the correct clinical methodology and the principles of evidence-based medicine. At the end of the course, the student must be able to critically evaluate both the value of the methodologies relevant to the biomedical laboratory, and the meaning of the data that can be obtained relating to human pathological conditions, deepening the knowledge of clinical biochemistry and clinical molecular biology on a single pathology, evaluate the analytical and biological circumstances that can lead to an incorrect interpretation of the results, put them in relation to the different pathophysiological situations. The ability to interpret laboratory data based on the knowledge of Clinical Biochemistry and Clinical Molecular Biology will be the expected learning outcomes.
Course Structure
Classroom lectures.
Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Required Prerequisites
Knowledge of biology, physiology, chemistry and general biochemistry
Attendance of Lessons
Detailed Course Content
Working diagnosis, from biological sample to the clinical report
Screening, Diagnosis, Monitoring of the progress of the disease and response to drugs
Pre-analytical, analytical and post-analytical phase
The error
Biological samples, blood, urine, faeces, CSF, saliva, cerebrospinal fluid, biopsies, bone marrow aspirate.
Main techniques used in clinical biochemistry and clinical molecular biology.
Biochemical-clinical profiles useful in the biomedical laboratory and related laboratory investigations: glucose profile, protein profile, lipid profile, hydro-saline and acid-base balance.
The liver and liver diseases and laboratory investigations
Cardio-circulatory system and laboratory investigations for heart attack, angina and heart failure.
Blood and blood count
Clinical biochemical evaluation of an inflammatory state: ESR, white blood cell counts, acute phase proteins, CRP
Hemostasis and blood coagulation and coagulation alterations
Kidney, renal failure and laboratory investigations
Textbook Information
Biochimica Clinica e Medicina di Laboratorio, Marcello Ciaccio e Giuseppe Lippi, Edises
Biochimica Clinica Essenziale, Elisabetta Albi, Tommaso Beccari e Samuela Cataldi, Zanichelli
Additional material supplied by the teacher;
Course Planning
| Subjects | Text References | |
|---|---|---|
| 1 | Working diagnosis, from biological sample to the clinical report | Biochimica Clinica e Medicina di Laboratorio, Marcello Ciaccio e Giuseppe Lippi, EdisesBiochimica Clinica Essenziale, Elisabetta Albi, Tommaso Beccari e Samuela Cataldi, ZanichelliMateriale didattico fornito dalla docente |
| 2 | Screening, Diagnosis, Monitoring of the progress of the disease and response to drugs | " |
| 3 | Pre-analytical, analytical and post-analytical phases | " |
| 4 | The error | " |
| 5 | Different types of biological samples | " |
| 6 | Main techniques used in clinical biochemistry and clinical molecular biology. | " |
| 7 | Biochemical-clinical profiles useful in the biomedical laboratory and related laboratory investigations: glucose profile, protein profile, lipid profile, hydro-saline and acid-base balance. | " |
| 8 | The liver and liver diseases and laboratory investigations | " |
| 9 | Cardio-circulatory system and laboratory investigations for heart attack, angina and heart failure. | " |
| 10 | Blood and blood count | " |
| 11 | Clinical biochemical evaluation of an inflammatory state: ESR, white blood cell counts, acute phase proteins, CRP | " |
| 12 | Hemostasis and blood coagulation and coagulation alterations | " |
| 13 | Kidney, renal failure and laboratory investigations | " |
Learning Assessment
Learning Assessment Procedures
Learning assessment may also be carried out on line, should the conditions require it.
Examples of frequently asked questions and / or exercises
Why request a laboratory investigation.
Diagnostic sensitivity and diagnostic specificity.
Jaundice.
The blood count
Plasma lipoproteins
Transaminases
Versione in italiano