In the last 15 years of the completion of the human genome project, the project "HapMap" project and "The Cancer Genome Atlas" (modified in “Cancer Genomics Cloud-CGC” from 2017) simultaneous development of "omics" technologies have been a major turning point for the understanding of the structure and the complexity of the genome and for the development of innovative technologies that would allow, in a short time and in a single experiment, the analysis of the genome, defining new diagnostic opportunities addressed to a personalized medicine.