BASI BIO FISICHE E MOLECOLARI

7 CFU - 1° Semester

Teaching Staff

MARINA SCALIA - Module Applied Biology - BIO/13 - 2 CFU
GIUSEPPE POLITI - Module FISICA - FIS/07 - 2 CFU
CARMELINA DANIELA ANFUSO - Module Biochemistry - BIO/10 - 3 CFU

Learning Objectives

Applied Biology
The course is designed to give students an integrated view of the basic cellular processes that regulate the activities of living organisms. The student will know the mechanisms of differentiation of the eukaryotic cell, the method and the molecular basis of the transmission of characters, the mechanisms of replication, translation and modification of genetic information. At the end the course the student should be able to prove that you have acquired the biological and molecular knowledge necessary for the understanding of normal and pathological biological phenomena.
Biochemistry
Students will learn a general knowledge on the molecular basis of life, from the fundamental chemical properties of the substances, the structure and function of macromolecules involved in life processes, both at the cellular and extracellular level , the metabolic transformations of biomolecules necessary for the human body function. In addition, students will understand the significance of the changes in key metabolic pathways in different physiological and pathological contexts.

Detailed Course Content

Applied Biology
The general characteristics of living matter. Cell Theory.Prokaryotic and Eukaryotic cell (structure and functions). Virus (mode of infection, lytic and lysogenic cycle). Chemical composition of living matter. Cell membranes: structure and function of the plasma membrane.The mechanisms of transport across the membrane (simple and facilitated diffusion, active transport). Mechanisms of signal transduction. Smooth and Rough Endoplasmic Reticulum, the Golgi Apparatus, Lysosomes and Peroxisomes. Nucleic Acids: structure and function of DNA and RNA. DNA replication. Mitosis and Meiosis. The human karyotype: normal and pathological karyotypes. The prokaryotic and eukaryotic gene: mechanism of the process of transcription in prokaryotes and eukaryotes. Regulation of gene expression in eukaryotes. Mendelian genetics: mode of transmission of hereditary characteristics. The meaning of meiosis.
Biochemistry
1. PROTEIN
2. CHROMOPROTEINS AND THE TRASPORT OF OXYGEN
3. PLASMA PROTEIN AND THEIR CLINICAL IMPLICATIONS
4. ENZYMES AND ENZYMATIC CATALYSIS
5. THE CARBOHYDRATE METABOLISM
6. THE LIPID METABOLISM
7. THE METABOLISM AMINOACIDS
8. VITAMINS
9. MECHANISM OF ACTION OF HORMONES AND METABOLIC INTEGRATIONS

Textbook Information

Applied Biology

1. Biology and Genetics: G. Chieffi, S.Dolfini, M.Malcovati Quarta Edizione EDISES

2. Elements of Biology and Genetics: Purves, Sadava, Orians, Heller, Editore Zanichelli.

3.Chimica, Biochemistry and Applied Biology Stefani e Taddei, Editore Zanichelli

Biochemistry
1. Introduzione alla Biochimica di Lehninger – D.L. Nelson, M.M. Cox – ZANICHELLI

2. Biochimica medica – Siliprandi, Tettamanti – PICCIN

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