METODOLOGIE DI EMBRIOLOGIA SPERIMENTALE

The course METHODOLOGIES OF EXPERIMENTAL EMBRYOLOGY aims are: to provide information on the main animal models used in the field of experimental embryology, to learn the main methodologies used for the study of alterations in normal development processes and to define morphologically and molecular responses to various stress factors and the mechanisms implemented by the latter to counteract any teratogenic effects.

Lessons, seminars and laboratory activities.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Learning assessment may also be carried out on line, should the conditions require it.

Main animal models used in experimental embryology. Innovative experimental approaches for the study of embryonic development. Definition of toxic substance. Short, medium and long term toxicity test. Teratogenesis, mutagenesis and carcinogenesis. Concept of toxic dose: minimum toxic dose, maximum toxic dose, lethal dose 50 (LD50). Fate of a xenobiotic in a living organism: routes of exposure and bioaccumulation. Factors Affecting Toxicity. Stress factors and cellular response.

Developmental Biology, Developmental Biology, Scott F. Gilbert, Michael J. F. Barresi, 2016.