GENERAL PATHOLOGY CONCEPTS: concept of health and disease, homeostasis, etiology, pathogenesis, pathological manifestations.
Pathology Genetics: Mutations and chromosomal abnormalities. Transmission mechanisms of genetic diseases in humans.
ENVIRONMENTAL PATHOLOGY AND NUTRITION: disorders of mechanical and thermal energy transfer. Pathologies by absorption of radiation. Disease by electric currents. Chemicals due to illness. Diseases from poor diet.
CELL DISEASE: Changes of growth and cell differentiation. Atrophy, hypertrophy, hyperplasia, metaplasia, anaplasia. Cell death: necrosis and apoptosis.
INFECTION AND INFECTIOUS DISEASES: infection, infections and infectious diseases.
INFLAMMATION: Acute and chronic inflammation. Phases of acute inflammation, vascular changes, cellular events and chemical mediators, inflammatory exudate, evolution and outcome of inflammation. Chronic inflammation, cytological aspects, granulomas. Systemic manifestations of inflammation.
IMMUNE SYSTEM: innate immunity and adaptive immunity; principal cells of the immune system: T-lymphocytes and B lymphocytes, antigens and antibodies, antigen-presenting cells, the complement system, cytokines.
REACTIONS IMMUNOPATOGENE
CANCER: The cell cycle. Changes in cell proliferation. Benign and malignant tumors. Criteria for the classification of tumors, grading and staging of tumors, the TNM system. Tumor markers. Carcinogenesis: oncogenic viruses, chemical and physical carcinogens. Oncogenes and tumor suppressor genes. microRNA
NOTES ON TEMPERATURE: fever and pathogenetic mechanisms.
PATHOPHYSIOLOGY OF REPLACEMENT electrolyte edema.
PATHOPHYSIOLOGY OF BLOOD: anemias, leukemias, lymphomas.
ATHEROSCLEROSIS – DIABETES MELLITUS.