CHIMICA E BIOCHIMICA BIOLOGIA E GENETICA - channel 2

5 CFU - 1° Semester

Teaching Staff

CRISTINA BARBAGALLO - Module Biology and Genetics - BIO/13 - 2 CFU
ANGELA MARIA AMORINI - Module CHIMICA E BIOCHIMICA - BIO/10 - 3 CFU

Learning Objectives

Biology and Genetics
The course aims to provide a preparation in Biology and Genetics suitable for understanding the basic notions of modern Cellular and Molecular Biology with hints of mendelian and human molecular Genetics. At the end of the module, the student will acquire the basic notions on the morphology and function of cellular systems, as well as on the mechanisms underlying the inheritance of characters and the flow of genetic information contained in the latter. Learning these concepts will therefore make clear to the student the mechanisms of transition from the genotype to the molecular and cellular phenotype, both in physiological and pathological conditions.
CHIMICA E BIOCHIMICA
The Chemistry and Biochemistry course aims to provide knowledge on the structure and characterization of biological molecules, as well as the chemical-physical foundations that regulate their ability to react and transform. The study of the fundamental metabolic pathways for vital processes, based on a molecular approach, aims to direct the student to the correlation with clinical disciplines.

Course Structure

Biology and Genetics
Frontal lessons.

If the teaching will be given in a mixed or remote way, the necessary changes may be introduced with respect to what was previously stated, in order to respect the program envisaged and reported in the syllabus.
CHIMICA E BIOCHIMICA
Frontal lessons

If the teaching is given in a mixed or remote way, the necessary changes may be introduced with respect to what was previously stated, in order to comply with the program envisaged and reported in the syllabus.
Information for students with disabilities and / or SLD

To guarantee equal opportunities and in compliance with the laws in force, interested students can ask for a personal interview in order to plan any compensatory and / or dispensatory measures, based on the didactic objectives and specific needs.

It is also possible to contact the referent teacher CInAP (Center for Active and Participated Integration - Services for Disabilities and / or SLD) of the Department

Detailed Course Content

Biology and Genetics
As requested prerequisite, general knowledge on the structure and function of the main biological macromolecules and on cellular informational metabolism is mandatory.

The course will develop as follows:

1) Introduction to the course: the eukaryotic and prokaryotic cell;
2) Organic macromolecules: proteins;
3) Organic macromolecules: nucleic acids;
4) DNA, chromatin and chromosomes;
5) Structure and function of genes;
6) Transcription in eukaryotes and prokaryotes;
7) Translation in eukaryotes and prokaryotes;
8) DNA duplication in eukaryotes and prokaryotes;
9) Mitosis and Meiosis;
10) Point mutations and chromosomal aberrations;
11) The Cell Membrane: structure and transport mechanisms;
12) Oncogenes, Oncosuppressants and Cancer;
13) Cenni di genetica mendeliana e di genetica umana
CHIMICA E BIOCHIMICA
Atoms, molecules; electronic models and structure of atoms, properties and periodic table of elements. Absolute and relative atomic masses, mole. The chemical bond. The solutions: concentrations, colligative properties. Basics of thermodynamics. The chemical equilibrium: properties, reaction rate, buffer systems. Electrochemistry. Characteristics of carbon compounds: classification and nomenclature (hydrocarbons, heterocyclic compounds), physical and chemical properties. Functional groups in organic chemistry: structure, characteristic reactions and biological purpose. Carbohydrates, lipids and proteins: structural and functional biochemical characteristics. Special proteins: hemoglobin and myoglobin. Enzymes: catalysis, kinetics and regulation. Bioenergetics. Carbohydrate, lipid metabolism and amino acid metabolism: main pathways and hormonal regulation. Vitamins and coenzymes.

Textbook Information

Biology and Genetics
Text 1. Biologia e Genetica. G. De Leo, S. Fasano, E. Ginelli. Ed. EdiSES

Text 2. Fondamenti di biologia e genetica. Riccardo Pierantoni, Gilda Cobellis, Rosaria Meccariello. Ed. EdiSES

Text 3. Elementi di biologia e genetica. David Sadava,David M. Hillis,H. Craig Heller. Ed. Zanichelli
CHIMICA E BIOCHIMICA
- 1.Massimo Stefani, Niccolò Taddei-Chimica & Biochimica- Zanichelli
- 2.Michele Samaja, Paroni Rita-Chimica e biochimica per le lauree triennali dell'area biomedica-Piccin 3.F. A. Bettelheim, W. H. Brown, M. K. Campbell, S. O. Farrell-Chimica e Propedeutica Biochimica- EdiSES
- 4.M. Bertoldi, D. Colombo, F. Magni, O. Marin, P. Palestini -Chimica e Biochimica- EdiSES
- 5.Siliprandi, Tettamanti-Biochimica Medica - Strutturale, metabolica e funzionale-Piccin
- 6.David L. Nelson, Michael M. Cox Lehninger Principles of Biochemistry Editor: W.H.Freeman & Co Ltd
- 7.BERG JM, TYMOCZKO JJL, STRYER L. Biochemistry Editor McMillan
- 8.VOET and VOET Biochemistry Editor Wiley

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