BIO/14 - 3 CFU - 2° Semester

Teaching Staff


Learning Objectives

At the end of the course the student must be able to evaluate, based on the knowledge of the pharmacodynamic and pharmacokinetic characteristics, the general properties of a drug and to envisage its possible therapeutic uses taking into account the structure, the mechanism of action, the kinetics as well as the relationship between pharmacological and toxicological effects. The student will be able to evaluate, through the study of the principles of pharmacodynamics, the relationships between structure-action, mechanism of action, dose-response relationship and measure of the pharmacological effect, as well as evaluation of efficacy and potency and pharmacodynamic interactions. By studying pharmacokinetics, the student will acquire knowledge on the routes of administration, metabolic transformations, pharmacokinetic models and calculations, pharmacokinetic interactions. Toxicology concerning the principles of general toxicology, side effects and adverse reactions to drugs and their evaluation, the criteria for the evaluation of the risk-benefit ratio, the mechanisms of drug addiction. Drug development, drug testing and regulation of medicinal specialties, concerning the origin and testing of molecules of pharmacological interest; the characteristics, requirements and methods of registration of medicinal products; the methods of prescription.

Course Structure

classroom lecture with ppt projections

Detailed Course Content

General principles of pharmacology, fundamental mechanisms that regulate pharmacokinetics, pharmacodynamics, cellular and molecular pharmacology; main factors responsible for the variability in drug response; clinical drug trials and ethics committees

Textbook Information

The Pharmacological bases of Therapeutics; Goodman and Gilman; McGraw Hill

Trattato di Farmacologia; Annunziato,Di Renzo; Idelson Gnocchi

Farmacologia generale e molecolare; Clementi-Fumagalli

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