PATOLOGIA GENERALE ED IMMUNOLOGIA - channel 3

The main objectives of the course will be aimed at understanding the tumor phenotype, the etiopathogenesis of cancer, the interactions with the immune system, the mechanisms of tumor progression and of the metastatic spread.

Lectures

Cellular alterations: dysplasia, metaplasia

Monoclonal origin of tumors

Definition and classification of tumors

Staging and grading of tumors

Epithelial–mesenchymal transition and metastasis

Cancer immune evasion

Hereditary and sporadic tumors

Immortalization and telomeres

Cell cycle regulation: pRB, c-myc

Maintainance of genomic integrity

The p53 gene

Alterations of intracellular signaling pathways in cancer

Growth factors and cancer

Tumor angiogenesis

Principles of oncological therapy

Weinberg: The Biology of Cancer, Garland Science

Pontieri-Russo-Frati: Patologia Generale. Piccin

Robbins & Cotran Pathologic Basis of Disease