SCIENZE BIOMEDICHE

9 CFU - 1° Semester

Teaching Staff

GIOVANNI GIURDANELLA - Module BIOCHIMICA - BIO/10 - 2 CFU
ANGELA TROVATO SALINARO - Module BIOCHIMICA CLINICA - BIO/12 - 2 CFU
KATIA DOMENICA MANGANO - Module General Pathology and Clinical Pathology - MED/04 - 3 CFU
LAURA TROVATO - Module Clinical Microbiology - MED/07 - 2 CFU

Learning Objectives

BIOCHIMICA CLINICA
The teaching of Clinical Biochemistry aims to provide to the students the basic and methodological notions to the comprehension and interpretation of the results obtained from the biochemical-molecular diagnostic investigations of biological samples for the characterization of conditions pathophysiology and pathology of organs and tissues. At the end of the course the student will acquire the knowledge of the biological and biochemical parameters and of the indicators of the alterations which are at the base of some diseases widely spread in the population.
General Pathology and Clinical Pathology
Following the programm of Pathology 1 , at the end of the course the student will have a knowledge of the main pathologies associated with the immune system, of the etiopathogenetic mechanisms of the tumor, escape mechanisms and immunotherapy. Students also will acquire the main notions of phisiopathology.
Clinical Microbiology
The course aims to provide students with the cognitive and methodological tools necessary for understanding the biological and pathogenetic characteristics of microorganisms and parasites responsible for human infections in different systems, as well as strategies for the control of such infections and signs of microbiological diagnostics.

Course Structure

BIOCHIMICA CLINICA
The course takes place through lecture with slide projection and practical exercises; in addition, there will be activities to be carried out independently or in groups. Interactive teaching is foreseen with participation in active working groups and quizzes, through the use of web platforms and Open Source software.
Written and oral exam. Written examination with multiple choice questions on all the topics covered during the course.
Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus. Learning assessment may also be carried out on line, should the conditions require it.
General Pathology and Clinical Pathology
Frontal Lesson

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Clinical Microbiology
Frontal Lesson. Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

Detailed Course Content

BIOCHIMICA CLINICA
Introduction to Clinical Biochemistry: collection, transport and storage, treatment and causes of alteration of biological samples.Analytical and statistical concepts in data analysis: pre-analytical, analytical and post-analytical variability, biological variability, diagnostic sensitivity and specificity, predictive value of a test, quality control of analytical methods.

Laboratory analysis in diseases of the liver and biliary tract. Markers of hepatic injury.

Laboratory analysis in cardiovascular diseases. Cardiac injury markers.

Laboratory analysis in kidney diseases. Indices of renal function.

Clinical molecular diagnostics.
General Pathology and Clinical Pathology
Immunodeficiencies

Oncology, escape mechanisms of the immune system and immunotherapy

Introduction General Pathology

Environmental pathology

Cellular pathology: cellular adaptations (hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia), apoptosis, necrosis

Inflammation: acute, chronic, inflammatory mediators

Fever and alterations of the temperature

Immune system: innate immunity, acquired (cell mediated and humoral)

Hypersensitivity: I, II, III e IV type

Atherosclerosis

Amyloidosis

Diabetes mellitus

General physiopathology of blood, hematopoietic organs and haemostasis.
Clinical Microbiology
- Biological essential features of microrganisms and parasites responsible for human infections
- The most important pathogens in infections of the respiratory tract, central nervous system, genito-urinary tract, gastrointestinal tract, skin, bones, joints and intravascular and cardiac infections
- Microbiological diagnostics.

Textbook Information

BIOCHIMICA CLINICA
1) Biochimica clinica essenziale. E. Albi, T. Beccari, S. Cataldi. Zanichelli.

2) Biochimica Clinica. Il quadro d'insieme. Lee W. Janson , Marc E. Tischler. Piccin.

3) Elementi di Biochimica Clinica e Medicina di Laboratorio. M. Ciaccio. EdiSES Università.
General Pathology and Clinical Pathology
Elementi di patologia generale per corsi di laurea in professioni sanitarie, Giovanni M. Pontieri – Piccin

Elementi di fisiopatologia generale GM Pontieri Ed. Piccin
Clinical Microbiology
Microbiologia Microbiologia clinica. R. Cevenini - V. Sambri. Ed Piccin

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