# METODOLOGIA DELLA RICERCA ED EPIDEMIOLOGIA

5 CFU - 2° Semester

### Teaching Staff

MASSIMO COSTANZO - Module STATISTICS - MED/01 - 3 CFU
GIUSEPPE NICOSIA - Module Computer engineering & Bioimaging - ING-INF/05 - 2 CFU

## Learning Objectives

• STATISTICS

Method of teaching course:
Lectures, active participation of students through questions, preparation of a questionnaire for data collection and subsequent data collection and exercises.

• Computer engineering & Bioimaging

The student will be introduced to the main methods for the generation of bioimaging.

## Course Structure

• STATISTICS

VALUTATION: Writing and oral exam

• Computer engineering & Bioimaging

The module includes lectures and tutorials.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.

## Detailed Course Content

• STATISTICS

1.Brief introduction to epistemology of knowledge
2. Scientific use
3. Types of measurement scales: nominal, ordinal, interval and ratio scales
4. Representation of data in graphs and tables
5. Central indicators, variability indicators, asymmetry and kurtosis
6. Probability, sum and product principle
7. Probability application
8. Diagnostic tests: sensitivity, specificity, predictive values
9. Relative risk and odds ratio
10. Probability distributions: binomial, Poisson and normal
11. Standardized Gaussian curve
12. Inference: central limit theorem, sample distribution of the mean and standard error
13. Confidence interval for the mean and variance
14. Hypothesis test: null and alternative hypotheses
15. Significance tests between two groups: Student t test for dependent and independent groups
16. Contingency tables and chi square test
17. Brief description of linear correlation and regression

• Computer engineering & Bioimaging

Introduction to Bioengineering.
Characteristics of image systems.
Medical imaging.
Ultrasound images.
Magnetic resonance imaging.
Reconstructive and other imaging techniques.
Artificial imaging of medical images.
Transmission and representation of bioimages.

## Textbook Information

• STATISTICS

Daniel W Biostatistica EdiSES Napoli 1996 pp 736

• Computer engineering & Bioimaging

Textbooks:
1. W. Mark Saltzman, Biomedical Engineering: Bridging Medicine and Technology, Cambridge Texts in Biomedical Engineering, Cambridge University Press, 2nd Edition, June 2015.
2. Giuseppe Coppini, Stefano Diciotti, Guido Valli, Bioimmagini, Collana di Ingegneria Biomedica (Diretta da Emanuele Biondi e Claudio Cobelli) Pàtron Editore, 2012.

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