SCIENZE CLINICHE

6 CFU - 2° Semester

Teaching Staff

PAOLO VIGNERI - Module ONCOLOGIA MEDICA - MED/06 - 2 CFU
CESARINA GIALLONGO - Module Hematology I - MED/15 - 2 CFU
CESARINA GIALLONGO - Module Hematology II - MED/15 - 2 CFU

Learning Objectives

Hematology I
The aim of the course is to allow the student to recognize the different hematological diseases with insights into methodology necessary to identify, classify and monitor: automated hematological methods, cytogenetics and molecular biology, flow cytometry, electrophoretic methods to measure specific analytes as markers of hematological malignancy.
Hematology II
The aim of the course is to allow the student to recognize the different hematological diseases with insights into methodology necessary to identify, classify and monitor: automated hematological methods,cytogenetics and molecular biology, flow cytometry, electrophoretic methods to measure specific analytes as markers of hematological malignancy.

Course Structure

Hematology I
Oral lessons
Hematology II
Oral lessons

Detailed Course Content

Hematology I
1. Structure of bone marrow and hematopoiesis

2. Evaluation of blood count and peripheral blood smears

3. Normocytic anemias (post hemorrhagic, caused by kidney disease or by maturation block)

4. Microcytic anemias and thalassemias

5. Macrocytic anemias (B12 and folate deficiency)

6. Hemoglobinopathies and hemolytic anemias

7. Pathophysiology of hemostasis

8. Platelet pathologies and hemorrhagic syndromes

9. Thrombosis
Hematology II
1. Cytogenetics and molecular biology in hematological malignancies 2. The role of the immunophenotyping in the diagnosis of hematological malignancies and for minimal residual disease evaluation 1. Acute Leukemias 2. Chronic myeloid leukemia 3. Chronic myeloproliferative neoplasms 4. Myelodysplastic syndromes 5. Hodgkin and non-Hodgkin Lymphomas 6. Chronic lymphocytic leukemia 7. Monoclonal Gammopathies and Multiple Myeloma 8. Transplantation of autologous and allogeneic hematopoietic stem cells

Textbook Information

Hematology I
1. "Malattie del sangue e degli organi emolinfopoietici" di Tura S., CAvo M., Zinzani P.L. - ESCULAPIO

2. “Manuale di Malattie del Sangue” di Alberto Bosi, Valerio De Stefano, Francesco Di Raimondo, Giorgio La Nasa. Elsevier

3. “Ematologia Per medicina, scienze biologiche, biotecnologie mediche” di N. Giuliani, A. Olivieri - Idelson-Gnocchi

4. “Manuale di ematologia” di Paolo Corradini, Robin Foà - Minerva Medica
Hematology II
1. "Malattie del sangue e degli organi emolinfopoietici" di Tura S., CAvo M., Zinzani P.L. - ESCULAPIO

2. “Manuale di Malattie del Sangue” di Alberto Bosi, Valerio De Stefano, Francesco Di Raimondo, Giorgio La Nasa. Elsevier

3. “Ematologia Per medicina, scienze biologiche, biotecnologie mediche” di N. Giuliani, A. Olivieri - Idelson-Gnocchi

4. “Manuale di ematologia” di Paolo Corradini, Robin Foà - Minerva Medica

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