The course aims to provide a preparation in Biology and Genetics suitable for understanding the basic notions of modern Cellular and Molecular Biology with hints of mendelian and human molecular Genetics. At the end of the module, the student will acquire the basic notions on the morphology and function of cellular systems, as well as on the mechanisms underlying the inheritance of characters and the flow of genetic information contained in the latter. Learning these concepts will therefore make clear to the student the mechanisms of transition from the genotype to the molecular and cellular phenotype, both in physiological and pathological conditions.
The course of Biochemistry aims to provide to the students the basis to understanding the physical, chemical and biological contexts in which molecules, reactions and metabolic pathways play their role.
At the end of the present course the student will understand the structure-function relationships of the main biological molecules, essential biochemical mechanisms that underlie a proper metabolic function and the consequences of their alterations.
If the teaching will be given in a mixed or remote way, the necessary changes may be introduced with respect to what was previously stated, in order to respect the program envisaged and reported in the syllabus.
Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
Learning assessment may also be carried out on line, should the conditions require it.”
As requested prerequisite, general knowledge on the structure and function of the main biological macromolecules and on cellular informational metabolism is mandatory.
The course will develop as follows:
1) Introduction to the course: the eukaryotic and prokaryotic cell;
2) Organic macromolecules: proteins;
3) Organic macromolecules: nucleic acids;
4) DNA, chromatin and chromosomes;
5) Structure and function of genes;
6) Transcription in eukaryotes and prokaryotes;
7) Translation in eukaryotes and prokaryotes;
8) DNA duplication in eukaryotes and prokaryotes;
9) Mitosis and Meiosis;
10) Point mutations and chromosomal aberrations;
11) The Cell Membrane: structure and transport mechanisms;
12) Oncogenes, Oncosuppressants and Cancer;
13) Cenni di genetica mendeliana e di genetica umana
In particular the course of Biochemistry will be devoted to clarificy molecular meccanism envolved during the study of ormonal and metabolic approaches in order to better underline the cross-talk between molecules that play a pivotal role in understanding the targets for the objectives to be analyzed set by biochemistry. and molecular biology.
4. Devlin. Biochimica con aspetti clinici. EdiSES