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SCIENZE DELLA PATOLOGIA UMANA

Teaching Staff

KATIA DOMENICA MANGANO - Module General Pathology - MED/04 - 2 CFU
MASSIMO CARUSO - Module Immunopathology - MED/04 - 2 CFU
MASSIMO CARUSO - Module TECHNIQUES OF IMMUNOPATHOLOGY - MED/04 - 2 CFU

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Learning Objectives

• General Pathology
  

  Know the causes of illness and their different nature: chemical, physical, biological (Etiology); know the different ways in which these causes bring damage to the organism (Pathogenesis); identify the organism's own defense mechanisms by studying the physiology of the Immune system and its functioning anomalies (Immunology and Immunopathology). The course will develop from the molecular level to higher grades of organization (cell, tissue, organ, apparatus, organism)

• Immunopathology
  

  At the end of the course the student will know the organization of the immune system, the main cells that compose it and the mediators through which the immune defences implement their action against etiologic agents. It will also know the pathology on an immune basis so as to be able to correctly perform and interpret laboratory tests for the study of the immune system and of the related pathological phenomena.

• TECHNIQUES OF IMMUNOPATHOLOGY
  

  Knowledge of the principles of immunological techniques for application in quantitative and diagnostic analyzes

Course Structure

• General Pathology
  

  Frontal lesson

• Immunopathology
  

  Lectures with the teacher with audio-visual support and slides that will be provided to students

• TECHNIQUES OF IMMUNOPATHOLOGY
  

  Lectures with the teacher with audio-visual support and slides that will be provided to students

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Detailed Course Content

• General Pathology
  
  • Introduction General Pathology
  • Genetic diseases
  • Environmental pathology
  • Cellular pathology: cellular adaptations (hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia), apoptosis, necrosis
  • Regeneration, repair and healing
  • Inflammation: acute, chronic, inflammatory mediators
  • Fever and alterations of the temperature
  • Tumors
  • Alteration of acid basic balance
  • Aterosclerosis
  • Amiloidosis
• Immunopathology
  

  - Immune system: innate immunity, acquired (mediated and humoral cell)

  - Antibodies and antigen-antibody reaction

  - Lymphocytes and their subpopulations

  - Cytokines and other mediators of the immune response

  - The immune system and tumors

  - Pathologies of immunological origin

  - Hypersensitivity

  - Autoimmunity

• TECHNIQUES OF IMMUNOPATHOLOGY
  

  - Antigen-antibody reaction

  - Monoclonal antibodies and their use in the laboratory

  - Enzyme-Linked Immunosorbent Assay (ELISA)

  - Immunofluorescence

  - Cytofluorimetry

  - Cell Functional Assays in the Laboratory

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Textbook Information

• General Pathology
  
  • Elementi di patologia generale per corsi di laurea in professioni sanitarie, Giovanni M. Pontieri – Piccin
  • Elementi di fisiopatologia generale. GM Pontieri - Ed. Piccin
• Immunopathology
  

  Immunopatologia – Biologia e Patologia del Sistema Immunitario – J.R. Regueiro González, C. López Larrea, S. González Rodríguez, E Martinez Naves – Piccin Editore

• TECHNIQUES OF IMMUNOPATHOLOGY
  

  Immunopatologia – Biologia e Patologia del Sistema Immunitario – J.R. Regueiro González, C. López Larrea, S. González Rodríguez, E Martinez Naves – Piccin Editore

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