Aim of this course is to provide the knowledge of the basic principles of pharmacokynetics and pharmacodynamics. The course is also designed to provide a specific knowledge of the pharmacological and toxic effects of drugs used for the treatment of neuropsychiatric disorders.
The main objectives of the course are as follows:
-To provide essential knowledge on the physiopathology of the acute and chronic diseases (e.g. chronic intestinal disease, autoimmune diseases, diabetes, pancreatitis) and to identify their relationship and inter-dependency.
-To apply these skills to the full spectrum of diseases in human.
-To develop the transferable skills on acute and chronic diseases (including physiopathology, oral communication with patients, team work, decision making during diseases) between students and patients.
The course develops skills in the Clinical Pathology aiming to teach the student to apply, evaluate and interpret the laboratory tests used to study of the main diseases of the blood, alterations of the coagulative-fibrinolytic system, changes in liver and kidney function, some endocrinopathies.
1. Knowledge and understanding: at the end of the course, students will acquire the knowlodge of the main laboratory tests to the study the blood diseases, the coagulative-fibrinolytic system, liver and kidney function alterations andsome endocrinopathies.
2. Ability to apply knowledge and understanding: once the knowledge of the main laboratory tests has been acquired, the students will be able to evaluate and interpret the aforementioned tests.
3. Making judgments: through the executions, the students will be able, independently, to apply, evaluate and interpret different laboratory tests.
4. Communication skills: the student will acquire the necessary communication skills within the main laboratory tests.
5. Learning skills: the aim of the course is to provide the student with the basic knowledge to autonomously interpret the main laboratory tests.
Lessons are held in the classroom with the help of PDF presentations made available to students on the Studium portal. The presentations do not replace the reference texts, but serve as educational support for the program carried out.
Pharmacokinetic and pharmacokinetic parameters (clearance, half-life, repeated dose toxicity, first pass effect, bioavailability and bioequivalence).
PHARMACODYNAMICS: Mechanisms and site of action of drugs.
receptor function and variability of drug response.
Agonism, antagonism competitive and non-competitive, affinity, intrinsic activity, effectiveness. dose-response curves, effective dose, lethal dose, therapeutic index, safety.
pharmacological and therapeutic effects, side effects, adverse reactions, overdose, intolerance to drugs, fetal toxicity; teratogenicity and carcinogenicity.
Drugs acting on the Central Nervous System (CNS): , antidepressants, anxiolytics and antipsychotics.
Diabete, pancreatiti acute pancreatiti croniche celiachia malattie acute renali malattie croniche renali malattie intestinali croniche (morbo di Crohn e rettocolite ulcerosa) - diabete mellito e inquadramento delle patologie su base autoimmune - distinzione tra malattie croniche e malattie acute in medicina interna; malattie croniche intestinali (morbo di Crohn e retto-colite ulcerosa) - celiachia e malattie da malassorbimento - insufficienza renale acuta e cronica - pancreatite acuta e cronica - cirrosi epatica
The course is organized in theoretical lessons combined with exercises aimed at interpreting the results of different types of laboratory analysis
Laboratory analysis: definition, typology
Collection and conservation of biological samples
Preanalytical, analytical and biological variability
Complete blood count test
Plasma proteins and electrophoresis
Urine analysis and functional kidney test
The functional liver test
Diabetes: diagnosis and follow up test
Farmacologia, Rossi - Cuomo - Riccardi, Edizioni Minerva Medica, III edizione.
Testo consigliato: RUGARLI MEDICINA INTERNA SISTEMATICA,
Rugarli C., Nuti R., Caligaris Cappio F., Cantalamessa L., Cappelli G., Cappellini M.D., CavalloPerin P., Corazza G. R., Craxì A., Crea F., Fabbri L., Ferraccioli G., Giustina A., Lazzarin A., Stella A.P.
1. Federici G. Medicina di Laboratorio. Mc Graw-Hill Companies.
2. Sacchetti L., Cavalcanti P. et. al. Medicina di laboratorio e diagnostica genetica. Sorbona
3. Laposata M. Medicina di Laboratorio. Piccin
4. Antonozzi I. Medicina di Laboratorio. Picci