The course target is, by means of common organic reaction mechanisms analysis, to develope student ability to correlate organic molecules (including some classes of biomolecules such as fatty acids, aminoacids, peptides and carbohydrates) properties and reactivities with their structures and to design synthetic strategies to prepare relatively simple target organic molecules after acquiring the fundamental principles of disconnession approach.
Acquire experiences on the methodologies and techniques on the organic synthesis through the preparation of some products and their identification
Fontal lessons and exercises on the course topics.
In room lectures. UV-Vis; IR, 1H-, 13C-NMR spectra interpretation
Aromatic hydrocarbons. Aromatic electrophilic substitution reactions. Aromatic nucleophilic reactions. Phenols. Pericyclic reactions. Carbanions as nucleophiles. Biomolecules (Lipids, Carbohydrates, Aminoacids and Proteins, Nucleic acids). Pentatomic Heterocycles. Pyridine. The disconnession approach.
Introductive ideas on common identification techniques as: 1H - e 13C-NMR, UV-Vis, GC, GC/MS e HPLC.
Practical execution of electrophilic aromatic substitution, carbonyl addition-elimination reactions, local anesthetic multistage synthesis.
Isolation, purification and characterization of the products obtained in the experiences through: : p.f., UV-Vis, IR, 1H- e 13C-NMR.
Chimica Organica; Brown/Foote/Inverson/Anslyn; Edises 5ed.
Lectures and exercises on the course topics.
D.L. Pavia, G.M. Lampman, G.S. Kritz, Introduction to Organic Laboratory, Saunder College Pubblishing.
2. R.M. Silverstein, F.X. Webster, Identificazione Spettroscopica di Composti Organici,
Ambrosiana.
3.The Organic Chem Lab Survival Manual: A Student's Guide to Techniques, James W. Zubrick