PATOLOGIA GENERALE ED IMMUNOLOGIA - channel 1

The main objectives of the course will be aimed at understanding: the etiological factors responsible for the alterations of cell function; the cellular and molecular pathogenic mechanisms of pathological processes; the mechanisms underlying the responses of the body's defense and immune system disorders, in particular: hypersensitivity reactions, the immunodeficiencies and autoimmune disorders; control mechanisms of cell proliferation and apoptosis.

Program of General Pathology

CONCEPT OF HEALTH AND OF DISEASE

PHYSICAL CAUSES OF DISEASE

CHEMICAL CAUSES OF DISEASES

CAUSES OF EATING DISORDERS

BIOLOGICAL CAUSES OF DISEASES

CELLULAR PATHOLOGY: Hypertrophy, atrophy, hypotrophy, aplasia, metaplasia, dysplasia, anaplasia, fibrosis, steatosis, hypoxia and anoxia, ischemia

CELL DEATH: FREE RADICALS, APOPTOSIS AND NECROSIS

PATHOLOGY OF EXTRA CELLULAR MATRIX: amyloidosis, collagenosis, fibrosis, hyalinosis

GENETICS PATHOLOGY AND CHROMOSOMAL ABBBERATION

INFLAMMATION: ACUTE AND CHRONIC INFLAMMATION

OUTCOMES OF AN INFLAMMATORY PROCESS: granulation tissue, repair processes

ATHEROGENESIS

FEVER

Program of Oncology

Morphological characteristics of tumors and tumor growth.

Biochemical atypia and genetic behaviour of neoplastic cells.

Cytological and histological features of the tumor

Cell proliferation and differentiation.

Molecular mechanisms of cell adhesion and their alterations.

Mechanisms of signal transduction and changes in signal transduction.

Benign and malignant tumors: classification criteria.

Precancerous lesions.

Invasiveness and metastasis.

Models of carcinogenesis, carcinogenesis by physical, chemical and biological agents.

Antigens and tumor markers.

Oncogenic viruses and cancer, oncogenes and tumor suppressor genes.

Hormones and cancer.

The genes that regulate apoptosis and genetic stability.

The immune response in tumors.

Hereditary susceptibility to cancer.

Program of Immunology

General characteristics of immune responses.
Innate immunity.

Cells and tissues of the adaptive immune system.
Antigen processing and presentation to T lymphocytes
Receptors for antigen and accessory molecules of T lymphocytes
Maturation, activation and regulation of lymphocytes.
Tolerance immunology.
Effector mechanisms of immune responses.
Immunopathology: hypersensitivity and autoimmunity.
Congenital and acquired immunodeficiencies.

PATOLOGIA GENERALE E FISIOPATOLOGIA -G. M. Pontieri - Piccin

PATOLOGIA- Stevens, Lowe, Scott - Casa Editrice Ambrosiana

PATOLOGIA GENERALE - Rubin-Strayer – PICCIN

CELLULE, TESSUTI E MALATTIA. PRINCIPI DI PATOLOGIA GENERALE - Majno-Joris - Casa editrice Ambrosiana

IMMUNOLOGIA CELLULARE E MOLECOLARE - ABBAS A.K. , LICHTMAN A. H. , PILLAI S. Elsevier Italia s.r.l., 2012, 8° edizione

IMMUNOBIOLOGIA - Janeway , Murphy - Piccin-Nuova Libraria - 2014