C.I. MICROBIOLOGIA E MICROBIOLOGIA CLINICA E PATOLOGIA GENERALE

6 CFU - 1° Semester

Teaching Staff

GIUSEPPE CHISARI - Module MICROBIOLOGIA E MICROBIOLOGIA CLINICA - MED/07 - 3 CFU
ANTONIO ARCIDIACONO - Module General Pathology - MED/04 - 3 CFU

Learning Objectives

MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Microorganisms: infection of the host
Analyze the different "types" of viral or bacterial infection; differentiate a viral infection from that induced by other microorganisms and parasites. Locate the report that microorganisms and parasites cause human with the host, characterizing the phenomenon of "infection". Analyze the factors and mechanisms that determine the spread of microorganisms in infectious processes.

Biological essential features of microorganisms and parasites responsible for human infections
Identify the structures and functions necessary to perform the metabolic processes (adhesion) and to determine the replication and infection. Classify microorganisms and parasites in the various stages of aggregation of living matter. Analyze the phenomenon of variation and mutation of microorganisms with antibiotic resistance.

Infection
Chemotherapy
Define the principle of "selective toxicity" finalizing the therapeutic use of antimicrobials. Describe and classify the inhibitory mechanisms, the site of action, the antibiotic spectrum of action, as well as for antiviral and antifungal substances. Analyze the ways of penetration in the body, the spread differential in the infected, the presence of antigens in the various districts of the organism (blood, secretions, excretions) for the purpose of "contagion" and laboratory diagnosis. Identify the different laboratory methods that allow the identification of the causative agent of infection and those necessary deepening of the biology of microorganisms and human parasites.
General Pathology
Which certain information base scientific inherent cellular pathology and tissue suitable for the preparation of the student for those materials which will be used after the completion of training.

Detailed Course Content

MICROBIOLOGIA E MICROBIOLOGIA CLINICA
1. The prokaryotic cell
  The organization of the bacterial cell
  1. Structure and function of the cell wall
  2. Cellular components
  3. Accessory components (capsule, flagella, pili)
  4. Biofilm
  5. The spore
2. Microorganisms and parasites: infection of the host
  1. Microorganism-host relationships.
  2. The microbial population normally resident in the human body.
  3. Essential characteristics and differences of bacteria, viruses, fungi, protozoa and other parasites known to infect humans.
  4. The pathogenic mechanisms of microorganisms.
  5. The various possibilities of infection and spread of infection.
  6. Infection control: key features of prevention and antimicrobial therapy
3. The pathogenesis of bacterial infection
  1. The phases of bacterial infection
  2. Pathogenicity and virulence
  3. Mechanisms of pathogenicity
  4. Bacterial toxins
  5. The host response to bacterial infection
4. Infection control
  1. Sterilization, disinfection and antisepsis
  2. The antimicrobial chemotherapy:
    1. Classification and main characteristic of principal groups of antibiotics
    2. Mechanism of action
    3. Susceptibility testing
5. The diagnostic principles of bacterial diseases
  1. Microscopic examination
  2. Direct diagnosis (culture methods)
6. Systematic Bacteriology (taxonomy, main characteristics, pathogenicity, infectious diseases, possibility of prevention, diagnosis and antibiotic chemotherapy): the streptococci; the staphylococci; the Enterobacteriaceae and anaerobic bacteria
7. The diagnostic principles of viral diseases
  1. Culture method
  2. Culture indendent and molecular methods
  3. Serological methods
8. The Fungi
  Characteristics of fungi and their metabolism
9. The hospital infections or nosocomial
10. Antibiotic resistance
General Pathology
Introduction to General Pathology with detailed study of the causes of diseases, cellular pathology, inflammation, immunology, oncology.

Textbook Information

MICROBIOLOGIA E MICROBIOLOGIA CLINICA
Most recent edition
- Principi di microbiologia medica - Antonelli G., Clementi M., Pozzi G., Rossolini G.M. - Casa Editrice Ambrosiana
- Microbiologia Medica - Murray P. R., Rosenthal K.S., Pfaller M. A. - Casa Editrice Elsevier.
- Principi di microbiologia medica - La Placa M. Edises
General Pathology
Pontieri: Patologia Generale (testo per professioni sanitarie)

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