Students will acquire knowledge about basic principles in Pharmacology, such as pharmacokinetics and pharmacodynamics, drugs mechanisms, signal transduction pathways, adverse drug reactions. Furthermore, an overview of major drug classes mainly used in hospital will be presented, to promote the correct use of drugs and to avoid eventual life-threatening adverse reactions or drug interactions.
Provide learners with knowledge to understand the implementation, interpretation and application of clinical trials in diseases of Internal Medicine. Analyze the various types of clinical studies. The following topics will be studied in detail: evidence-based medicine (Evidence-Based Medicine, EBM), levels of evidence, degree of recommendations, consensus conferences, guidelines, recommendations based on studies available in Internal Medicine and diagnostic-therapeutic protocols in Internal Medicine. Clinical trials will be illustrated and analyzed in the management of the most frequent internal diseases (cardiocirculatory, metabolic, gastroenterological, pulmonary, neoplastic).
• Pharmacokinetics and pharmacodynamics;
• Dose-response relationships;
• The Drug Development Process;
• Factors affecting response to drugs;
• Risks and precautions for a proper drug therapy;
• Adverse drug reactions;
• Drug therapy during pregnancy and across the life span.
• Drugs affecting autonomic nervous system;
• Drug therapy for depressions and anxiety disorders;
• Drugs affecting the cardiovascular system;
• Drugs affecting the digestive system;
• Anti-inflammatory and anti-allergy drugs;
• Drugs used for diabetes mellitus;
• Basic principles in antimicrobial and antitumor chemotherapy.
Knowledge of the main pathologies of international interest of the gastrointestinal system, of the liver, of the cardio-circulatory system, of the respiratory system, of the kidney, of lipid metabolism and of glucose metabolism. Knowledge of biostatistics elements.