STRATEGY IN ORGANIC SYNTHESIS AND LABORATORY

This course is designed to be an intensive survey of the chemical methods and

strategies utilized in modern synthetic organic chemistry, focusing on Chemo-, Regio- and Stereoselectivity aspects. Emphasis will be placed on functional group transformations and carbon-carbon bond forming reactions.

Planning organic syntheses .

Retrosynthetic Analysis. Synthetic strategy based on functional group interconversion, activating groups, reversal of polarity. Protectin groups. The order of events. Chemoselectivity. Regioselectivity. Stereoselectivity.

Organo-main group chemistry in organic synthesis (sulfur, boron, silicon, tin). Cap 46-47

Organometallic reactives. Cap48

Introduction to ring synthesis. Cap29

Total synthesis of interesting and/or useful natural products

Modern strategy in minimizing the environmental impact of human industry and technology

There are no required texts for this course. However, a number of excellent reference texts can be particularly useful.

F. A. Carey & R. J. Sundberg "Advanced Organic Chemistry, Part B"

Warren, Wyatt- Organic Synthesis: the Disconnection approach 2 ed. Wiley 2011

Clayden, Greeves, Warren, Wothers Organic Chemistry – Oxford Univ Press 2001

Green chemistry