IDENTIFICATION OF DRUGS A - L

Preliminary testing: Organoleptic Test, test Combustion, organic elemental analysis, quantitative elemental analysis, examination of the chemical, solubility test.
Physical Constants: Melting Point, Boiling Point, Density, Refractive index,
Polarimetry (specific rotatory power: determination of specific rotatory power; scheme of the instrument, determination of optical purity).

Recognition of Functional Groups:
Carboxylic acids, hydroxy acids, phenols, alcohols, aldehydes and ketones, esters, lactones, anhydrides, ethers, halogen derivatives, amines, amides, amino acids, nitro compounds, aromatic hydrocarbons.

IR spectroscopy

Spectroscopy molecular absorption: General
Classical model, quantum model, frequency group, polyatomic molecules Interpretation of the IR spectrum
Instrumentation
Sample preparation and recording of the spectrum
applications

MASS spectrometry

the instrumentation
Ionization techniques
Analysis of fragmentation in EI analyzers
Tandem mass spectrometry Applications of mass spectrometry

Monographs: benzoic acid, ascorbic acid, tartaric acid, methyl and propyl p-hydroxybenzoate, acetylsalicylic acid, benzocaine, adrenaline, saccharin, paracetamol.

DEFINITION OF ANALYTICAL PROFILES OF THE FOLLOWING CLASSES OF DRUGS
-Sulfonamides: a) Antibiotics (sulfonamides) b) Antidiabetic agents (sulphonylureas) c) Diuretics -Carbohydrates: glucose, fructose, lactose, sucrose

-Benzodiazepine -Steroids
-Beta-lactam antibiotics

- F. Savelli, O. Bruno. Analisi Chimico Farmaceutica. Elementi di Analisi Qualitativa e Metodi Applicati ai Farmaci della European Pharmacopoeia. Ed. Piccin – Padova.
- V. Cavrini, V. Andrisano. Principi di Analisi Farmaceutica, terza edizione. Società Editrice Esculapio, 2013.
- A. Carta, M.G. Mamolo, F. Novelli, S. Piras. Analisi Farmaceutica Qualitativa. EdiSES, 2011.
- Varie ed. Farmacopea Ufficiale.
- Medicamenta