SCIENZE MEDICO CHIRURGICHE E FARMACOLOGICHE
8 CFU - 1° Semester
Teaching Staff
GUIDO NICOLA ZANGHI' - Module CHIRURGIA GENERALE - MED/18 - 3 CFU
CLAUDIO BUCOLO - Module Pharmacology - BIO/14 - 3 CFU
CLAUDIO BUCOLO - Module PHARMACOTOXICOLOGY - BIO/14 - 2 CFU
Detailed Course Content
- Pharmacology
The student must to know the following topics:
- Routes of drug administration ( Clark, chapter 1)
- Drug absorption (Clark chapter 1)
- Drug distribution (Clark chapter 1)
- Drug metabolism (Clark chapter 1)
- Drug elimination (Clark chapter 1)
- PK parameters (Clark chapter 1)
- Drug-Receptor interactions (Clark chapter 2 and 3)
- Agonists and antagonists (Clark chapter 2)
- Signal transduction (Clark chapter2)
- Desensitization and tachyphylaxis (Clark chapter2)
- Sympathetic neurons, adrenergic agonists and antagonists (Clark chapter 3, 6, 7)
- Parasympathetic neurons, cholinergic agonists and antagonists (Clark chapter 3, 4, 5)
- Autacoids (Clark chapter 3 and 42 )
- Therapeutic index, DE50, DT50 (Clark chapter 2)
- PHARMACOTOXICOLOGY
The student must to know the following topics:
- Development of new drugs: pre-clinical and clinical phases (slides)
- ADR classification (slides)
- Pharmacovigilance (slides)
- ATC classification (slides)
- Carcinogenesis, mutagenesis e teratogenesis (Goodman Chapter and slides)
- Chromatography in pharmacotoxicology (slides)
- Variability in the response to drugs (slides)
- Drugs interactions (Clarck chapter1 /slides)
- assessment of environmental risk (Goodman Chapter 67)
- Drug allergies (slides)
Textbook Information
- Pharmacology
Clark et al. Pharmacology. Lippincott;
- PHARMACOTOXICOLOGY
Clark et al. Pharmacology. Lippincott; Goodman & Gilmans “The Pharmacological Basis of Therapeutics, Twelfth Edition
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