METODOLOGIA CLINICA APPLICATA AGLI STUDI DI RICERCA

8 CFU - 1° Semester

Teaching Staff

GIOVANNA BRANCATO - Module CHIRURGIA GENERALE APPLICATA AI TRIALS CLINICI - MED/18 - 2 CFU
MARIANGELA CHISARI - Module Pharmacology: safety in therapy management - BIO/14 - 2 CFU
GUGLIELMO TROVATO - Module MEDICINA INTERNA APPLICATA AI TRIALS CLINICI - MED/09 - 2 CFU
MARIA CLORINDA MAZZARINO - Module PATOLOGIA GENERALE APPLICATA AI TRIALS - MED/04 - 2 CFU

Learning Objectives

Pharmacology: safety in therapy management
Students will acquire knowledge about basic principles in Pharmacology, such as pharmacokinetics and pharmacodynamics, drugs mechanisms, signal transduction pathways, adverse drug reactions. Furthermore, an overview of major drug classes mainly used in hospital will be presented, to promote the correct use of drugs and to avoid eventual life-threatening adverse reactions or drug interactions.
PATOLOGIA GENERALE APPLICATA AI TRIALS
The aim is to give the student the basic knowledge necessary to define causes and pathogenic mechanisms involved in diseases.

Detailed Course Content

Pharmacology: safety in therapy management
General Pharmacology

• Pharmacokinetics and pharmacodynamics;
• Dose-response relationships;
• The Drug Development Process;
• Factors affecting response to drugs;
• Risks and precautions for a proper drug therapy;
• Adverse drug reactions;
• Drug therapy during pregnancy and across the life span.

Drug classes

• Drugs affecting autonomic nervous system;
• Drug therapy for depressions and anxiety disorders;
• Drugs affecting the cardiovascular system;
• Drugs affecting the digestive system;
• Anti-inflammatory and anti-allergy drugs;
• Drugs used for diabetes mellitus;
• Basic principles in antimicrobial and antitumor chemotherapy.
PATOLOGIA GENERALE APPLICATA AI TRIALS
Cellular pathology: acute and chronic cell injury. Apoptosis and necrosis.

Acute and chronic inflammation: cells and chemical mediators of inflammation. Wound healing. Fever.

Immunology and immunopathology: innate and adaptative immunity. Immunological tolerance. Antigens and antibodies. The histocompatibility antigens and rejection of grafts. Hypersensitivity reactions. Immunodeficiencies. Autoimmune diseases.

Oncology: chemical, physical and biological causes of tumors. Oncogenes and tumor suppressor genes. Local growth and metastasis.

Textbook Information

Pharmacology: safety in therapy management
1. Hitner, Nagle, Principi di Farmacologia, Zanichelli
2. Rang, Dale, Farmacologia, Ed. Elsevier Masson
3. Rossi, Cuomo, Riccardi, Farmacologia - Principi di base e applicazioni terapeutiche, Minerva Medica
PATOLOGIA GENERALE APPLICATA AI TRIALS
Pontieri et al. Patologia Generale. Piccin Nuova libraria.

Robbins et al. Basi Patologiche Malattie: Patologia Generale. Elsevier

Mak, Saunders. Fondamenti di Immunologia, Zanichelli.

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