CHEMISTRY OF BIOACTIVE NATURAL PRODUCTS

Introduction. Drug discovery and drug development. Structure-activity relationship (SAR). Interaction with receptors. Enzyme inhibitors. Xenobiotics metabolism. Nutraceuticals and cancer chemoprevention.

Acetate biosynthetical pathway.

Mevalonate biosynthetical pathway.

Shikimate biosynthetical pathway.

Alkaloids: biosynthesis and properties.

Natural products containing sulphur or alogens.

1. Paul M. Dewick, Chimica, Biosintesi e Bioattività delle Sostanze Naturali, 2^a Ediz.,Piccin

2. Richard B. Silverman, The Organic Chemistry of Drug Discovery and Drug Action, 2^nd edition, Elsevier – Academic Press

3. Slides of the lessons