FARMACOLOGIA

In the first part of the present course, students will acquire information about basic principles in Pharmacology, from drug development processes to pharmacokinetics and pharmacodynamics, drugs mechanisms, signal transduction pathways, factors affecting response to drugs, adverse drug reactions. In the second part, students will be introduced to an overview of selected drug classes and their clinical applications.

Lectures. Students are invited to actively participate with questions, comments and thoughts related to covered topics.

In case lectures will be held in a mixed condition (both in front of students and online) or online only, required changes will be adopted even if not clearly stated in this section, in order to comply the planned program as reported in the Syllabus

General Pharmacology

• Foundations of Pharmacology;
• The Drug Development Process;
• Routes of administration;
• Pharmacokinetics: absorption, distribution, metabolism, excretion;
• Pharmacodynamics: biological targets, classification of receptors and theories, concentration-response curve;
• Signal transduction pathways;
• Agonists and antagonists;
• Factors affecting response to drugs;
• Adverse drug reactions

Drug classes

• Neurotransmitters and neuromodulators (synthesis, metabolism, distribution, functions, targets, drugs): acetylcholine, adrenaline and noradrenaline, dopamine, serotonin, GABA, glutamate, histamine, opioids, arachidonic acid;
• General and local anesthetics;
• Drugs used for cardiovascular and renal system, and for haemostasis and thrombosis;
• Drugs used for diabetes;
• Hints on drugs affecting the gastrointestinal tract;
• General basis of antibacterial and anticancer chemotherapy.

1. Rossi - Cuomo - Riccardi: Farmacologia - Principi di base e applicazioni terapeutiche, Minerva Medica, Edizione III and subsequent

2. Rang - Dale: Farmacologia, Ed. Edra, Edizione VIII and subsequent

3. Katzung - Preziosi - Masters – Trevor: Farmacologia Generale e Clinica, Piccin, Edizione IX and subsequent