Resistenze e sviluppo di nuove strategie antimicrobiche

BIO/19 - 6 CFU - 2° Semester

Teaching Staff

FLORIANA CAMPANILE
MARIA CARMELA SANTAGATI


Learning Objectives

The aim of the course is to introduce the student to the study of the mechanisms of action and resistance of the main classes of antibiotics and to the characterization of microorganisms with probiotic properties potentially usable in new antimicrobial strategies. The student will be taught the main knowledge relating to the application of bacteriological diagnostics and bacteriotherapy.


Course Structure

The course is organized in 42 hours of frontal teaching with the aid of slides. The discipline is divided into 2 modules of 21 hours each (Module I and II).

Frontal classes.

Compulsory course attendance.

Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.



Detailed Course Content

The growing increase in microbial infections is compounded by the rapid emergence and spread of antibiotic-resistant and often multi-drug-resistant (MDR) clones - resistant to more than three antibiotic classes.

The content of module I of the course reflects the growing importance of the antibiotic resistance problem related to the availability of new antibiotics introduced in clinical practice.

The student will be taught the main knowledge relating to:

- Strategies for acquiring resistance to conventional antimicrobials (AMRs).

- Mechanisms of action of the main antibiotic classes, with particular reference to new antibiotics.

- Related resistance mechanisms.

Due to the slowdown in the development of new antibiotics, the use of microorganisms with probiotic properties characterized by antagonistic activity towards specific microorganisms assumes an important role allowing to interfere and/or inhibit pathogenic strains.

Therefore, in the course of module II the knowledge relating to:

- Microbial genomics with particular attention to gene organization also addressed to its application in the biotechnology field.

- Characterization of the human microbiota / microbiome with metagenomic analysis.

- Characterization of bacterial strains producing bacteriocins with probiotic characteristics for its potential use in bacteriotherapy.



Textbook Information

1) Gianni Dehò e Enrica Galli. Biologia dei microrganismi. Casa editrice Ambrosiana.

2) During the lectures additional material (scientific articles from international journals) will be distributed for the study of specific issues.

3) https://www.ncbi.nlm.nih.gov/




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