The aim of general pathology course is to provide the basis for understanding the pathological mechanism involved in development of human diseases. During the course, the causes of diseases (etiology), the mechanism by which the etiological agents cause pathological condition (pathogenesis) will be discussed. Finally, will be elucidated the molecular and cellular mechanisms that allow the organism to counteract the effects of pathogens and other harmful agents.
The course aims at providing the student with the main notions on the functioning of organs and systyems in the human body. At the end of the course students should have acquired the basic principles governing normal and integrated functions of the body, as well as a good command of the scientific and physiological terminology,
The teaching will be carried out through the provision of classroom teaching lessons.
Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus.
The learning assessment consists of an oral test on the contents indicated in the program.
Learning assessment may also be carried out on line, should the conditions require it.
Lectures. Attendance is mandatory
PLEASE NOTE: The recent COVID-19 emergency has imposed the adoption of remote teaching and examination. As the emergency is unfortunately still on, remote teaching and examination is to be carried out in the coming months, therefore some changes may occur in order to closely adhere to the program outlined in the syllabus
General pathology: etiology and pathogenesis
Hereditary, environmental and infectious disorders
Immunology and immunopathology
Inflammation and wound healing
Fever and Hyperthermia
Cellular pathology
Oncology
Physiopathology of cardiovascular disease
Physiopathology of respiratory system
Physiopathology of muscular system
Cell membranes Transport mechanisms, ion channels
Nervous system General organization of the central, peripheral and autonomous nervous system. Main features of neurons and glia and their functions. Excitable membranes: Rest potential, local potentials, action potential and its propagation. Classification of nerve fibers.
Muscle Structure and organization of skeletal muscle. Excitation-contraction coupling. Twitch, summation and tetanus of skeletal muscle, Muscle metabolism, Motor unit. Smooth muscle.
Synaptic transmission Electrical and chemical synapses, neuromuscular junction, central synapses. Neurotransmitters.
Sistemi sensoriali Sensory receptors proprio- end esteroceptive sensitivity
Spinal cord: organization, mono- e polysynaptic reflexes. Spinal shock.
Hints on the functions of brainstem, cerebellum, basal ganglia and cerebral cortex. Movement disorders: Parkinson's disease
Cardiovascular system Features of cardiac muscle. Common and specific myocardium, conduction system, ECG. Cardiac cycle. Features of blood vessels, arteries, veins, capillaries. Factors influencing blood flow, laminar and turbulent blood flow. Circulation in arterial, capillary and venous vessels. Regulation of blood pressure.
Respiratory system Superior and inferior airways. Respiratory mechanics, pulmunar ventilation, Surfactant. Gas exchange and transport. Regulation of breathing, central and peripheral chemoceptors
Urinary system Renal functions: glomerular ultrafiltration, tubular reabsorption and secretion. Regulation of water-electrolytic and acid-base balance
Digestive system Hints on motility, secretion and absorption
ELEMENTI DI PATOLOGIA GENERALE & FISIOPATOLGIA GENERALE per i Corsi di Laurea in Professioni Sanitarie - GM Pontieri - IV edizione - PICCIN
PATOLOGIA GENERALE Patologia d’organo e molecolare - Rubin - VI Edizione - PICCIN
Silverthorn - FISIOLOGIA UMANA. UN APPROCCIO INTEGRATO - PEARSON
Conti (a cura di ) - FISIOLOGIA DELL’UOMO Edi- Ermes
Fox - FISIOLOGIA UMANA Piccin