Students will have to describe the main mechanisms underlying cancer pathogenesis and will have to define the appropriate procedures required for the diagnosis of female patients diagnosed with cancers of the breast, the ovary, the uterus and the cervix. Description of the general clinical setting of these diseases will also be required as well as a critical description of the management strategies employed for pregnant patients undergoing cytotoxic chemotherapy for a concomitant neoplastic disease. Critical emphasis will be dedicated to the identification and the management of Hereditary Breast and Ovarian Cancer (HBOC) Syndrome
At the end of the course, students should be able to:
Describe the types of genetic variation seen in the human genome and explain how these variations affect disease states and diversity of normal variation. Perform pedigree analysis and apply principles of inheritance in calculating genetic risk for a variety of genetic disorders and patterns of inheritance; and incorporate knowledge of population genetics to calculate genetic risk based on carrier frequency within a population. Explain and identify non-Mendelian mechanisms such as: reduced penetrance, variable expressivity, uniparental disomy, mosaicism, genomic imprinting and unstable repeat expansion. Understand the molecular basis of developmental and cancer genetics. Know the basic principles of Genetic counselling.
The goal of the project is the first time that the European Union has been given the opportunity to do so.
Frontal Teaching and Interactive Discussion
FRONTAL LESSONS
frontal teaching.
Should teaching be carried out in mixed mode or remotely, it may be necessary to introduce changes with respect to previous statements, in line with the programme planned and outlined in the syllabus
FRONTAL LESSONS
IF IT IS NECESSARY FOR THE SITUATION OF UNCERTAINTY LINKED TO COVID-19 EVEN IN MIXED MODE
Tumor Biology
Epidemiology and Cancer Prevention
· Incidence, Prevalence and Mortality Rates in Oncology
· Risk Factors for the Most Common Tumors
· Primary, Secondary and Tertiary Prevention
Treatment of the Most Common Forms of Female Cancer
· Breast Cancer
· Ovarian Cancer
· Cancer of the Uterus and the Cervix
Pregnancy Management in Women with Cancer
· Conventional Chemotherapeutic Drugs
Treatment of the Most Common Forms of Female Cancer
· Breast Cancer
· Ovarian Cancer
· Cancer of the Uterus and the Cervix
Hereditary Breast and Ovarian Cancer
· BRCA1 and BRCA2 genes
· Correlation between alterations in BRCA1 and BRCA2 genes and Breast Cancer
a. Array-CGH
b. Next generation sequencing
c. Non invasive prenatal testing
WOMAN ASSISTANCE WITH GYNECOLOGICAL PATHOLOGIES
SECONDARY AND TERTIARY PRIMARY PREVENTION
SUPPORTING THE WOMAN WITH MALIGNA PATHOLOGY
INSTRUMENTAL SURVEY
Collegio degli Oncologi Medici Italiani - Manuale di Oncologia Medica - 2018 - Edizioni Minerva Medica
Genetica Umana e Medica (Neri, Genuardi), seconda edizione, Elsevier
Medical Genetics (Jorde, Carey, Bamshad) fifth edition, Elsevier
LADEWING-LONDON-DAVIDSON "PICCIN MATERNITY ASSISTANCE"