METALLOMICA CON ELEMENTI DI PROTEOMICA

Knowledge of interactions and functional connections
of metal ions and their species with genes, proteins, metabolites, and other
biomolecules

Lessons and powerpoint presentations

Introduction

Review of inorganic chemistry for the studying of the metal ions in the biological systems

Homeostasis of the main metal ions in the prokaryotic and eukaryotic cells. Metal Transport and storage.

Structure and function of the main metalloproteins.

Pathologies related to the metal dyshomeostasis.

Ionophores and chelators as therapeutic agents.

Platinum Complexes.

Course materials will be available during the lessons.

R.R. Crichton Biological inorganic chemistry

Wolfgang Maret Metallomics: A Primer of Integrated Biometal Sciences Imperial College Press 2016

Metallomics and the Cell, Springer 2013