FISIOLOGIA GENERALE - PATOLOGIA GENERALE

14 CFU - 1° and 2° Semester

Teaching Staff

GIAMPIERO LEANZA - Module PHYSIOLOGY - BIO/09 - 8 CFU
KATIA DOMENICA MANGANO - Module General Pathology - MED/04 - 6 CFU

Learning Objectives

PHYSIOLOGY
Knowledge of organism function, from basic molecular mechanisms to the function of cells and whole organs, as well as organ functional integration in complex beings. Full knowledge of all the subjects included in the program below. Ability to analyze and synthesize subjects, understanding mechanisms in details and subsequently summarizing functional finalities. Ability to expose subjects clearly and extensively. Understanding that a full knowledge of Physiology subjects is essential to exert a profession in pharmaceutical and medical fields.

Having participated to Physiology classes, students will achieve knowledge on the mechanisms governing the functioning of the various apparatuses of the body, also acquiring advanced notions of anatomical organization and physiopathology.
General Pathology
At the end of the course the student will understand the underlying causes and pathogenetic mechanisms of human diseases, as well as the etiology of the fundamental alterations of the structures, functions and mechanisms of control. They will also know the basic biological mechanisms of defence and their alterations. The course will develop from the molecular level to higher grades of organization (cell, tissue, organ, apparatus, organism)

Course Structure

PHYSIOLOGY
Lectures
General Pathology
Frontal lesson

Detailed Course Content

PHYSIOLOGY
1. The organization of living beings. Structure of the human body: composition and fluid distribution.
2. Exchanges between intra- and extracellular compartments. The plasma membrane: composition, structure and selective permeability.
3. Transports across the plasma membrane. Diffusion. Osmosis. Cell membrane transport proteins. Active transport of substances through membranes.
4. Membrane ion channels. Active and passive ion channels.
5. Membrane potentials. Passive properties of cell membrane. The neuron. Action potentials: genesis and propagation.
6. Transmission of signals between excitable cells. Synaptic transmission. Electrical synapses: gap junctions. Chemical synapses: morphology and general properties. The neuromuscular junction. Neuronal synapses. Origin of post-synaptic potentials: neurotransmitters, neuromodulators and their receptors. Pre- and post-synaptic modulation of post-synaptic potentials. Synaptic integration processes: temporal summation and space summation of post-synaptic potentials.
7. Skeletal muscle physiology. Resting potential and action potential in skeletal muscle fibers. Molecular mechanisms of muscle contraction. Role of calcium in muscle contraction. Excitation-contraction coupling. Characteristics of whole-muscle contraction. Isotonic and isometric modes of contraction.
8. Smooth muscle structure and function. Resting and action potential in smooth muscle cells. Molecular mechanisms of smooth muscle contraction. Nervous and hormonal control of smooth muscle contraction.
9. Cardiac muscle physiology. Resting potential and action potential in pacemakes cells and in cardiomyocytes. Molecular mechanisms of cardiac muscle contraction.
10. Organization of the nervous system: central and peripheral structures.
11. Sensory function of the nervous system. Somatic sensations: general organization. Sensory receptors. Transmission of somatosensory impulses to the central nervous system.
12. The tactile and position senses. Pain and thermal sensations.
13. The chemical senses: taste and smell.
14. The sense of hearing. Inner ear receptors. Central auditory mechanisms.
15. The sense of vision. The eye: optics of vision. Receptor and neural function of the retina. Central neurophysiology of vision.
16. The organization of voluntary movement: cortical and brainstem control of motor function. Motor cortex, supplementary areas, cerebellum, basal ganglia, spinal cord. Vestibular sensations and maintenance of equilibrium. Disturbances of voluntary movements: Parkinson's disease
17. Reflex responses: general properties. Spinal reflexes.
18. Higher functions of the brain, learning and memory. Cerebral cortex. The hippocampus. Pathological memory loss: Alzheimer's disease
19. Behavioural and motivational mechanisms in the brain: the limbic system and the hypothalamus.
20. States of brain activity. The sleep-wake cycle. Epilepsy. Psychoses.
21. The autonomic nervous system and the adrenal medulla: general organization. Basic characteristics of sympathetic and parasympathetic function. Autonomic reflexes.
22. The endocrine system. Hormones: structure, function, mechanisms of action. Regulation of hormone secretion.
23. Pituitary hormones and their control by the hypothalamus.
24. Insulin, glucagon and diabetes mellitus.
25. Adrenocortical hormones.
26. Thyroid metabolic hormones.
27. Parathyroid hormone, calcitonin, vitamin D: role in calcium and phosphate metabolism.
28. The cardiovascular system: anatomy and general properties.
29. Blood: composition and functions.
30. The heart as a pump: anatomy and function. Structure of cardiac valves. Excitatory and conductive system of the heart. Control of excitation and conduction. Cardiac cycle. Electrocardiogram.
31. Overview of the circulation. Biophysics of pressure, flow and resistance. Structure and function of blood vessels: arteries, veins and capillaries. Local and humoral control of tissue blood flow. Regulation of blood pressure.
32. The microcirculation and lymphatic system: capillary fluid exchange, interstitial fluid and lymph flow.
33. Homeostasis of volume and osmolarity of extracellular and intracellular fluids. The kidney and urinary system. Glomerular filtration, renal blood flow and their control. Tubular reabsorption and secretion processes. Role of the kidney in the regulation of body fluids and electrolytes. Role of the kidney in long-term regulation of blood pressure.
34. Acid-base regulation.
35. The respiratory system. Pulmonary ventilation. Pulmonary circulation. Physical principles of gas exchange. Transport of oxygen and carbon dioxide in blood and tissue fluids. Regulation of respiration.
36. Digestive system: anatomy and functional organization. Neural control of motility and secretion. Gastrointestinal blood circulation. Mechanical and chemical processes of digestion. Digestion and absorption of carbohydrates, proteins and lipids. Structure and function of the liver.
37. Energy metabolism. Dietary balance and regulation of feeding.
38. Body temperature regulation and fever.
General Pathology
- Introduction General Pathology
- Alterations acid-base balance
- Genetic diseases
- Environmental pathology
- Cellular pathology: cellular adaptations (hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia), apoptosis, necrosis
- Regeneration, repair and healing
- Inflammation: acute, chronic, inflammatory mediators
- Fever and alterations of the temperature
- Immune system: innate immunity, acquired (cell mediated and humoral)
- Evasion of host defences
- Primary and acquired immunodeficiencies (AIDS)
- Hypersensitivity: I, II, III e IV type
- Immune tolerance
- Autoimmunity: pathogenetic mechanisms and some autoimmune diseases (multiple sclerosis, rheumatoid arthritis, type I diabetes)
- Tumors
- Atherosclerosis
- Amyloidosis

Textbook Information

PHYSIOLOGY
Carbone, Aicardi, Maggi - FISIOLOGIA. DALLE MOLECOLE AI SISTEMI INTEGRATI – EDISES

Silverthorn - FISIOLOGIA UMANA. UN APPROCCIO INTEGRATO - PEARSON
General Pathology
- Elementi di patologia generale per corsi di laurea in professioni sanitarie, Giovanni M. Pontieri – Piccin
- Patologia generale di Maurizio Parola

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