At the end of the course the student will have to know the main types of diagnostic cytopathology exams, be able to set up and color the cytological preparations, know the basic principles of reactive and neoplastic cellular pathology; it must also be able to apply the general concepts of cytopathology to the main types of cytological samples.
Management of surgical biopsy
Preparation of histological specimen
needle aspiration cytology
Preparation of cyologic specimen
fluorescent in situ hybridization
Anatomic Patholohy-cellular damage
Cellular response to stress. Reversible and irreversible cellular damage. Apoptosis. Cellular response to ischemia. Molecular mechanisms of cellular death. Coagulative, colliquative, caseous, rubbery, haemorragic, fat and fibrinous necrosis.
Anatomic Patholohy-the disorders of proliferation and cellular differentiation: hyperplasia, metaplasia and neoplasia
Cellular cycle. Cell proliferation in histological sections. Hyperplasia and hypertrophy. Metaplasia. Neoplasia: benign and malignant. Preneoplastic lesions: dysplasia and in situ neoplasia. Morphological invasiveness and metastasis. Histological grading of malignancy. Stadiation (TNM). Tumor classification. Molecular basis of tumor.
Anatomic Patholohy-flogosis and diseases of immune system.
Acute and chronic flogosis. The organ specific autoimmune diseases (Sjogren syndrome, Goodpasture syndrome, Graves disease) and systemic (SLE, rheumatoid arthritis, sclerodermia)
Diseases of lymphonodes
Non Hodgkin lymphoma
Main anatomical aspects of heart failure; ischemic heart disease: epidemiology and classification, evolution and complications. Myocarditis: epidemiology and classification. Cardiomyopathies: epidemiology and classification; evolution. Heart transplant. Valve pathology: epidemiologyl and classification of the main acquired valvular defects. Cardiac tumors. Pericarditis.
Atherosclerosis: epidemiology and histological alterations: evolution of plaque. Arteriolosclerosis. Vasculitis: classification. Aneurysms: classification and evolution.
Inflammatory pathology of the lung: epidemiology and anatomical classification. Lung tumors: metastases and primitive tumors: epidemiology and classifications; grading and staging of primitive tumors. Prognostic and predictive markers. Pleuritis. Primitive and metastatic tumors of the pleurae.
Small round blue cell tumors: neuroblastoma, rhabdomyosarcomas, Ewing / pPNET sarcoma, Wilms' tumor, lymphoblastic lymphomas, Burkitt's lymphoma, small round cell desmoplastic tumor of the abdominal cavity.
1)Robbins - Cotran "Le basi patologiche delle malattia" 9a edizione Elsevier
2)Gallo - D’Amati Anatomia Patologica – La sistematica” UTET