Students will have to describe the main mechanisms underlying cancer pathogenesis and will have to define the appropriate procedures required for the diagnosis of female patients diagnosed with cancers of the breast, the ovary, the uterus and the cervix. Description of the general clinical setting of these diseases will also be required as well as a critical description of the management strategies employed for pregnant patients undergoing cytotoxic chemotherapy for a concomitant neoplastic disease. Critical emphasis will be dedicated to the identification and the management of Hereditary Breast and Ovarian Cancer (HBOC) Syndrome.
the course aims at the acquisition of skills regarding genetic diseases, the genetic component of multifactorial diseases, genetic counseling, clinical approach, diagnostic techniques, genetic tests, ethical problems.
The goal of the project is the first time that the European Union has been given the opportunity to do so.
Frontal Teaching and Interactive Discussion
FRONTAL LESSONS
Tumor Biology
Epidemiology and Cancer Prevention
· Incidence, Prevalence and Mortality Rates in Oncology
· Risk Factors for the Most Common Tumors
· Primary, Secondary and Tertiary Prevention
Treatment of the Most Common Forms of Female Cancer
· Breast Cancer
· Ovarian Cancer
· Cancer of the Uterus and the Cervix
Pregnancy Management in Women with Cancer
· Conventional Chemotherapeutic Drugs
Treatment of the Most Common Forms of Female Cancer
· Breast Cancer
· Ovarian Cancer
· Cancer of the Uterus and the Cervix
Hereditary Breast and Ovarian Cancer
· BRCA1 and BRCA2 genes
· Correlation between alterations in BRCA1 and BRCA2 genes and Breast Cancer
General information on genetic diseases. Frequency and clinical importance of genetic diseases. Genes and environment as a cause of illness. Malformative syndromes. Family trees Mendelian diseases. Characteristics of autosomal dominant mendelian diseases. Characteristics of autosomal recessive mendelian diseases. Characteristics of sex linked diseases, Dominant or Recessive. Genetic heterogeneity. Digenic inheritance. Polygenic and multifactorial diseases. Epigenetics. Imprinting, uniparental disomy. Dynamic mutations. Mitochondrial diseases. Chromosomal diseases, chromosome microdelection /microduplication syndromes. Genomic variants. Balanced chromosomal alterations. Mosaicism. Loss of heterozygosity. Oncogenetics. Genetic counseling. Prenatal-postnatal diagnosis. Chromosomal and genomic analysis : traditional karyotype, FISH, CGH array, SNP array. DNA tests: Molecular analysis: search for known mutations, MLPA, Sanger sequencing, NGS. Sequence variants, duplication/deletions.Guidelines. Informed consent. Ethical problems.
WOMAN ASSISTANCE WITH GYNECOLOGICAL PATHOLOGIES
SECONDARY AND TERTIARY PRIMARY PREVENTION
SUPPORTING THE WOMAN WITH MALIGNA PATHOLOGY
INSTRUMENTAL SURVEY
Collegio degli Oncologi Medici Italiani - Manuale di Oncologia Medica - 2018 - Edizioni Minerva Medica
1) Genetica umana e medica 4 edizione 2017 di Giovanni Neri e Maurizio Genuardi Masson
2) Lecture notes
LADEWING-LONDON-DAVIDSON "PICCIN MATERNITY ASSISTANCE"