The course allows the student to acquire the knowledge about the vital functions of man and the cellular mechanisms of the major biological systems. It analyzes the integrated functioning of the different organs and systems of control by which the living organism obtains and maintains the homeostasis inside.
During the course of the lessons there will be written tests and oral interviews in the appeals indicated in the exam calendar. About it, the student will receive a pdf of some topics covered in class.
Composition, organization, structural asymmetries - Intercellular junctions.
Exchanges between cells and the environment
Simple diffusion through membranes - Diffusion through channels: channel selectivity, leakage channels ("always" open) and gated channels (equipped with "ports"), water channels (aquaporins) - Mediated transports: membrane carriers, facilitated diffusion, primary and secondary active transports - Movement of water through the membranes: osmosis - Vesicular transports: phagocytosis, pinocytosis, exocytosis - Exchanges through epithelia.
Ionic flows and electrical effects
Ionic equilibria - Diffusion potential and equilibrium potential - Electrical properties of membranes - Genesis of membrane potential.
Characteristics of the action potential: refractoriness, accommodation - Signal conduction along nerve fibers: velocity, myelination - Electrical properties of the myocardial fibers of pacemaker fibers and non-specific ones - Skeletal and smooth muscle fibers: electrical, mechanical and metabolic aspects of contraction - Ca2 + ions in muscle contraction.
Communication between cells
Mechanisms, modulation and control of endocrine communication: hormones, receptors, second messengers - Synaptic communication: electrical and chemical synapses, pre- and post-synaptic mechanisms, neurotransmitters and neuromodulators, space-time summation, plasticity (LTP and LTD) - Synapse neuro -Muscle.
Coding of sensory information
Receptor complexes: classifications, definition of stimulus, threshold and receptive field - Mechanisms of transduction and coding - Receptor sensibility - Spinal reflexes.
Control of vegetative functions
Nervous system organization - Integrated programs: hypothalamic functions.
Blood: composition, functions, gas transport, hematopoiesis.
Hemodynamics (velocity, pressure, resistance, flow regimes) - Functions of the arteries: elastic properties, arterial pulse - District and systemic control of peripheral resistance - Capillary exchanges - Venous return
Cardiac function: automatism, mechanical and electrical properties, intrinsic and extrinsic regulation.
Ventilation in aquatic and terrestrial environments - Mechanical aspects of pulmonary ventilation: dead spaces, respiratory volumes, intrapleural and alveolar pressure, compliance, surface tension - Alveolus-capillary diffusion - Control of ventilation: bulbo-pontine centers, intrinsic rhythm, chemical and mechanical regulation .
Internal environment regulation
Renal mechanisms: filtration, reabsorption, secretion - Excretion of metabolic waste - Water balance: concentration of urine - Control of volume, osmolarity and acid-base balance of body solutions.
Digestive system: motility, secretions and absorption - Exocrine pancreas - Role of bile - Nervous and chemical control of gastrointestinal functions.
D.U. Silverthorn, Fisiologia umana, Casa Editrice Ambrosiana;
R. Hill, G. Wyse, M. Anderson, Fisiologia animale, Zanichelli;
D. Schimdt-Nielsen, Fisiologia animale, Piccin.