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PATOLOGIA GENERALE E CLINICA MICROBIOLOGIA E ANATOMIA PATOLOGICA - channel 2

Teaching Staff

FERDINANDO NICOLETTI - Module PATOLOGIA GENERALE E CLINICA - MED/04 - 2 CFU
MARIO SALMERI - Module MICROBIOLOGIA E MICROBIOLOGIA CLINICA - MED/07 - 2 CFU
LUCIA SALVATORELLI - Module Anatomic Pathology - MED/08 - 2 CFU

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Learning Objectives

• PATOLOGIA GENERALE E CLINICA
  

  The main objectives of the course will be aimed at understanding: the etiological factors responsible for the alterations of cell function; the cellular and molecular pathogenic mechanisms of pathological processes; the mechanisms underlying the responses of the body's defense and immune system disorders, in particular: hypersensitivity reactions, the immunodeficiencies and autoimmune disorders; control mechanisms of cell proliferation and apoptosis.

• Anatomic Pathology
  

  Knowledge of the basic of human pathology, in particular cellular, morphological, immunophenotypical and molecular alterations of inflammatory , immune and neoplastic diseases. Organization of the laboratory of pathology, in particular methods of histo-cytopathology, immunofluorescence, immunohistochemistry and molecular biology

Course Structure

• PATOLOGIA GENERALE E CLINICA
  

  frontal lessons

• Anatomic Pathology
  

  biweekly

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Detailed Course Content

• PATOLOGIA GENERALE E CLINICA
  

  Introduction General Pathology

  Environmental pathology

  Cellular pathology: cellular adaptations (hyperplasia, hypertrophy, atrophy, metaplasia, dysplasia), apoptosis, necrosis

  Inflammation: acute, chronic, inflammatory mediators

  Fever and alterations of the temperature

  Immune system: innate immunity, acquired (cell mediated and humoral)

  Hypersensitivity: I, II, III e IV type

  Anemie

• Anatomic Pathology
  

  Introduction to pathological anatomy

  Compilation of a histo-cytopathological form

  Method of fixation of biological material by formalin. Stages of preparation of a histological preparation: sampling, processing, paraffin embedding, cutting, staining.

  Intraoperative examination: methods of execution, indications, examples of applicability.

  Incisional and excisional biopsy; endoscopic biopsy.

  Diagnostic cytology: exfoliative, needle aspiration, by apposition: applications.

  Immunohistochemical technique.

  Concepts of hyperplasia, hypertrophy, atrophy, aplasia, hypotrophy, metaplasia, dysplasia, carcinoma in situ.

  Benign and malignant neoplasm: differences. Classification of neoplasms.

  Invasive carcinoma. Tumor histological grade. Metastasis: lymphatic and blood. Tumor staging system: TNM.

  Apoptosis Versus necrosis

  Knowledge of the main pathologies of the gastrointestinal tract: Barrett's esophagus, esophageal carcinoma; chronic intestinal inflammatory diseases (Crohn's disease, ulcerative rectocolitis), colon polyps (hyperplastic polyp, colorectal adenomas), colo-rectal carcinoma.

  Knowledge of the main thyroid diseases: goiter, Basedow disease, thyroiditis, thyroid tumors (follicular adenoma, follicular carcinoma, capillary carcinoma, undifferentiated carcinoma, medullary carcinoma).

  Knowledge of the main pathologies of the breast (fibrosis-cystic mastopathy, fibroadenoma, carcinoma in situ and invasive carcinoma); sentinel lymph node;screening methods.

  Knowledge of the main lung cancer pathologies (histology classification, clinical and action staging methods).

  Knowledge of the main uterine pathologies (causes of uterine bleeding, leiomyomas and leiomyosarcomas).

  Knowledge of the main pathologies of the urinary tract (cystitis and benign and malignant urothelial tumors).

  Knowledge of the main tumors of the skin (squamous carcinoma, basal cell carcinoma, melanocytic nevi, melanoma).

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Textbook Information

• PATOLOGIA GENERALE E CLINICA
  

  Elementi di patologia ghenerale. GM Pontieri - Ed. Piccin

• Anatomic Pathology
  

  A.Scarpa, L.Ruco - Anatomia patologica. Le basi

  Gallo-D’Amati - Anatomia Patologica Sistematica.

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